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KMID : 0381120220440040415
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Genes and Genomics
2022 Volume.44 No. 4 p.415 ~ p.423
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CALM1 rs3179089 polymorphism might contribute to coronary artery disease susceptibility in Chinese male: a case-control study
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Huang Jingyan
Huang Siyun
Li Jinhong
Li Minhua
Gong Lin
Li Tongshun
Gu Lian
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Abstract
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Background: Calmodulin 1 (CALM1) mutations are involved in the development of coronary artery disease (CAD). However, the relationship of CALM1 rs3179089 polymorphism with CAD is unknown.
Objective: This study aimed to identify the relationship of CALM1 rs3179089 polymorphism with CAD susceptibility, CALM1 expression, blood pressure, blood glucose, blood coagulation and serum lipid levels of CAD patients.
Methods: 550 CAD patients and 550 control subjects were genotyped for CALM1 using Sequenom MassARRAY technology. CALM1 expression level was measured by quantitative real time polymerase chain reaction (qRT-PCR).
Results: CALM1 mRNA expression was higher in CAD patients than that in control subjects (P?
Conclusion: CALM1 expression is associated with development of CAD. CALM1 rs3179089 polymorphism affects CAD susceptibility in males, and blood pressure, blood glucose, blood coagulation and serum lipid of CAD patients.
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KEYWORD
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CALM1, Polymorphism, Coronary artery disease, Susceptibility, CAD-related risk factors
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